Yes, it can probably be done. SC2 supports both offine, and now with patch 5.0 online map-to-map loading. You would have to utilize bank files a lot to get this system to work correctly. It has been a while since I've played the Rexar Campaign, so I think loading the maps all works similarly.
For example, say you kill a pre-placed mob on map 1, then go to map 2, then back to map 1, the pre-placed mob would return unless you specified that it died via bank data. Also the fog of war would reset each time you load into a new map.
Offline map loading trigger: "Set Next Map" action
Online map loading trigger: "Online Map To Map Load" action